Crystalline form of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S314000, C514S311000, C546S177000, C546S178000, C546S180000

Reexamination Certificate

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06982334

ABSTRACT:
The present invention comprises crystalline forms of 3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid, represented by the structure:and as characterized herein by powder X-ray diffraction patterns as form A and form B, processes for preparing form A from the purified amorphous form of (3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid, a processes for preparing form A by heating monohydrated form C of (3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid, a pharmaceutical composition comprising form A, a pharmaceutical composition comprising form A and form B or monohydrated form C, a pharmaceutical composition comprising form A, form B and monohydrated form C, a method for treating a bacterial infection with form A, a method for treating a bacterial infection with form A and form B or monohydrated form C, and a method for treating a bacterial infection with form A and form B and monohydrated form C.

REFERENCES:
patent: 6403610 (2002-06-01), Malleron
patent: 2004/0147554 (2004-07-01), Bourget
Rouhi AM. Chemical & Engineering News, Feb. 2003, pp. 32-34.
Untitled, Rompp Lexikon Chemie, Georg Thierne Verlag, Stuttgart XP002245011, pp. 3976-3977.
Untitled, Rompp Lexikon Chemie, Georg Thierne Verlag, Stuttgart XP002245011, pp. 2275-2276.

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