Crystalline form III of N.sup..alpha. -[[(S)-4-oxo-2-azetidinyl]

Details Crystalline form III of N.sup..alpha. -[[(S)-4-oxo-2-azetidinyl] Crystalline form III of N.sup..alpha. -[[(S)-4-oxo-2-azetidinyl]

1986-12-03

1988-04-26

Schwartz, Richard A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Tripeptides, e.g., tripeptide thyroliberin , etc.

540200, C07D20508

Patent

active

047405864

ABSTRACT:
A novel crystal form of N.sup..alpha. -[[(S)-4-oxo-2-azetidinyl]-carbonyl]-L-histidyl-L-prolinamide is provided and a process for preparing such crystals. The crystals provided by the present invention are the dihydrate form of the compound which exhibits a specific X-ray powder diffraction pattern, infared absorption spectrum and thermogravimetry-differential scanning calorimetry. The compound in its novel crystal form is useful in the treatment of consciousness disturbances and memory disorders.

REFERENCES:
patent: 4537900 (1985-08-01), Kreidl et al.
patent: 4564609 (1986-01-01), Tamura et al.
Haleblian, J. et al., J. Pharm. Sci., 58(8), 913-917 (1969).

Affiliated with

Also associated with

Rating

Crystalline form III of N.sup..alpha. -[[(S)-4-oxo-2-azetidinyl] does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystalline form III of N.sup..alpha. -[[(S)-4-oxo-2-azetidinyl], we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystalline form III of N.sup..alpha. -[[(S)-4-oxo-2-azetidinyl] will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-820391