Crystalline form III of agomelatine, a process for its...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C564S216000, C564S219000

Reexamination Certificate

active

07635721

ABSTRACT:
Crystalline form III of the compound of formula (I):characterized by its powder X-ray diffraction diagram.Medicinal products containing the same which are useful in the treatment of melatoninergic disorders.

REFERENCES:
patent: 0447285 (1991-09-01), None
patent: 1564202 (2005-08-01), None
J. Haleblian, Pharmaceutical Applications of Polymorphism. Journal of Pharmaceutical Science, Aug. 1969 vol. 58(8) pp. 911-929.
S.R.Byrn, Solid State Chemistry of Drugs, 1999, 9gs. 62-63.
A.M. Rouhi, The Right Stuff, Chemical Engineering and News, Feb. 24, 2004, pp. 32-34.
H. G. Brittain, Polymorphisms in Pharmaceutical Solids, 1999, pp. 331-361.
Tinant, B. et al., “N-[2-(7-methoxy-1-naphthyl)ethyl]acetamid E, a potent melatonin analog” ACTA Crystallographic section C. Crystal structure communications, vol. C50, No. 6, p. 907-910, 1994.
Depreux, P., et al., “Synthesis and structure-activity relationship of novel naphthalenic and bioisosteric amidic derivatives as melatonin receptor ligands” Journal of Medicinal Chemistry, vol. 37, No. 20, p. 3231-3239, 1994.
Chilman-Blair, K., et al., “Agomelatine antidepressant treatment of bipolar disorder melatonin agonist/5-HT20 antagonist” Durgs of the Future, vol. 28, No. 1, p. 7-13, 2003.
Preliminary Search Report for FR 0508276 of Jul. 11, 2006.

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