Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2002-05-28
2003-12-16
Huang, Evelyn Mei (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S094000, C424S451000, C424S456000, C424S461000, C424S474000, C424S489000
Reexamination Certificate
active
06664267
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a new crystalline form of a fluoroquinolone, viz. arginine salt form thereof, a novel process for manufacturing the novel arginine salt form of the fluoroquinolone, the use of the novel form of the arginine salt of the fluoroquinolone in the manufacture of pharmaceutical formulations and the use of the novel form of the arginine salt of the fluoroquinolone in medicine. More particularly, it relates to the arginine salt form of the chiral fluoroquinolone S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for preparing the same and its use in pharmaceutical formulations and medicine.
BACKGROUND OF THE INVENTION
The chiral fluoroquinolone known under the name S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid is described in JP Patent 63,192,753A, JP Patent 05,339,238A, and in our pending U.S. patent applications Ser. Nos. 09/566,875, 09/640,947 and 09/802,793 and WO 00/68229, PCT Application Nos. PCT/IN00/00111 and PCT/IN01/00097.
S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid is an optically active isomer of the racemic compound which is claimed in U.S. Pat. No. 4,399,134.
S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid has an aqueous solubility of 0.8-2.0 mg/ml over the pH range 8.0-9.5 at 28° C., thus creating problems in having to formulate the drug as a tablet or capsule, or in making formulations for gavage and parenteral injection. The need for a salt is clearly indicated, as the lack of an appropriate salt form can hinder the development of dosage forms acceptable for systemic use in mammals.
S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid has a pKa value of 6.80 suggesting a weak acid character and thus an ability to form a salt with an appropriate base. Generally, conversion of a pharmacologically active compound into a salt form induces a change in the compound's physicochemical properties such as solubility, absorption velocity, etc.
Pharmaceutically more desirable salt forms may be selected by studying whether or not a crystalline or amorphous form, or polymorph or pseudopolymorph can be produced, and determining the properties including its physicochemical or biological properties. A pseudopolymorph is a polymorph that differs from a true polymorph by the incorporation of solvent (Solid-state Chemistry of Drugs, 2
nd
Ed. S. R. Byrn et al (Eds). SSCI, Inc. 1999, p-514).
Pharmaceutically acceptable salts of racemic 9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid such as salts with inorganic bases and organic bases are mentioned in the text of Otsuka's U.S. Pat. No. 4,399,134. Besides salts with inorganic bases and organic bases, amino acid salts of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid are identified in our pending U.S. patent applications Ser. No. 09/566,875 and U.S. patent application Ser. No. 09/640,947, WO 00/68229 and PCT Application No. PCT/IN00/00111. Arginine salt forms of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid are identified in our pending U.S. patent application Ser. No. 09/802,793 and PCT Application No. PCT/IN01/00097. The subject matter of these applications is incorporated herein by reference. To date, no literature reference teaches about the amino acid salts of RS-(+/−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid or R-(+)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid.
S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, L-arginine salt 0.25 hydrate and S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, L-arginine salt, 0.75 hydrate described in Examples 7 and 8 of U.S. patent applications Ser. Nos. 09/566,875 and 09/640,947, WO 00/68229 and PCT Application No. PCT/IN00/00111 respectively are highly hygroscopic and turn into syrups on exposure at a relative humidity of 41%. Additionally, arginine salt forms described in our pending U.S. patent application Ser. No. 09/802,793 and PCT Application No. PCT/IN01/00097 are either amorphous or only partially crystalline and are to a certain degree hygroscopic. Many hydrates and salts associated with water are susceptible to changes in humidity, are hygroscopic under adverse storage conditions and during pharmaceutical processing of them to medicament forms.
The amino acid salts, inorganic base and alkali salts and organic base salts and specially the arginine salt forms of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid were prepared and studied by the inventors and it was found that:
(a) an arginine salt may exist in a crystalline form having distinctive physicochemical, solubility and stability properties;
(b) the crystalline arginine salt is less prone than the sodium salt to absorb moisture at specified humidity levels;
(c) the crystalline arginine salt, possesses a lower propensity to cause phlebitis than the sodium and potassium salts as determined in rats by intravenous administration; and
(d) the crystalline arginine salt is less toxic in rodents than the alkali salt forms.
In summary, the crystalline form of the arginine salt of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid has been found by the inventors to have very desirable properties in possessing under specified conditions, less hygroscopicity, favourable aqueous solubility, a low propensity to cause phlebitis, and favourable acute toxicity values. This form is expected to be very useful as a pharmaceutical agent as compared with the previously described arginine salt forms, sodium salt, other inorganic base/alkali salts, organic base salts and other amino acid salts. These advantages will be apparent from the experimental data shown hereafter.
SUMMARY OF THE INVENTION
New arginine salts of RS-(±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, R-(+)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid and S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid are described. Compositions comprising one or more of these salts and methods for preparing the salts are described. The use of the salts in medicine is also described.
More particularly, a new L-arginine salt form of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid of the formula I
is described in which x denotes 0, 0.25, 0.5, 0.75, 1.0, 2.0 or 3.0. The novel crystalline form of the L-arginine salt of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid can be used in full scale manufacturing of pharmaceutical formulations.
Antibacterial compositions comprising the S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt form as an active component are described.
REFERENCES:
patent: 3924
de Souza Noel J.
Deshpande Prasad K
Gupte Shrikant V
Jaweed Mukarram Siddiqui M
Kulkarni Dilip Ganesh
Huang Evelyn Mei
Ladas & Parry
Wockhardt Limited
LandOfFree
Crystalline fluoroquinolone arginine salt form does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Crystalline fluoroquinolone arginine salt form, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystalline fluoroquinolone arginine salt form will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3177639