Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-09-23
2008-09-02
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S469000
Reexamination Certificate
active
07420068
ABSTRACT:
The present invention discloses crystalline particles of escitalopram oxalate which either have a broad particle size distribution or comprise at least 0.01% (w/w) of Z-4-(4-dimethylamino-1-(4-fluorophenyl)-but-1-enyl)-3-hydroxymethyl-benzonitrile, said particles being suitable for use in direct compression.Furthermore, the invention discloses a novel pharmaceutical unit dosage form containing such crystalline particles of escitalopram oxalate as well as methods for manufacture of such crystalline particles of escitalopram oxalateFinally, the invention provides a method for reduction of the amount of hydroxyl containing impurities in a solution of citalopram or escitalopram.
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PCT International Search Report of International Appln. No. PCT/DK2005/000115.
Christensen Troels Volsgaard
Humble Rikke Eva
Jensen Kim Bojstrup
Liljegren Ken
Chandrakumar Nizal S
Darby & Darby P.C.
H. Lundbeck A/S
Seaman D. Margaret
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