Crystalline antibiotic salt

Details Crystalline antibiotic salt Crystalline antibiotic salt

1984-12-03

1986-06-10

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 20, C07D50112

Patent

active

045944172

ABSTRACT:
Crystalline cephalosporin hydrochloride salt represented by the formula ##STR1## wherein the oxime is in the syn configuration, is a useful pharmaceutical form of, and tool for purification of, the corresponding antibiotic free base; processes for its preparation are provided.

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patent: 4278671 (1981-07-01), Ochiai et al.
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patent: 4298607 (1981-11-01), Natsugari et al.
patent: 4411897 (1983-10-01), Schartazzini
patent: 4467086 (1984-08-01), Miller
Wheeler, et al.; "Orally Active Esters of Cephalosporin Antibiotics . . . ", J. Med. Chem. (22) pp. 657-661 (1979).
Miller, Thomas, "Improvement of Cephalosporin Antibiotics", Chem. Abst. 95: 86304(y) (1981).

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