Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-10-25
2011-10-11
Noakes, Suzanne M (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C436S004000
Reexamination Certificate
active
08034906
ABSTRACT:
The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions.
REFERENCES:
patent: 5231024 (1993-07-01), Meoller et al.
patent: 5656272 (1997-08-01), Le
patent: 6090382 (2000-07-01), Salfeld et al.
patent: 6258562 (2001-07-01), Salfeld et al.
patent: 6448380 (2002-09-01), Rathjen
patent: 6451983 (2002-09-01), Rathjen
patent: 6498237 (2002-12-01), Rathjen
patent: 6509015 (2003-01-01), Salfeld et al.
patent: 7070775 (2006-07-01), Le
patent: 7192584 (2007-03-01), Le
patent: 7223394 (2007-05-01), Salfeld et al.
patent: 7250165 (2007-07-01), Heavner
patent: 7276239 (2007-10-01), Le
patent: 7541031 (2009-06-01), Salfeld et al.
patent: 7588761 (2009-09-01), Salfeld et al.
patent: 7863426 (2011-01-01), Wan et al.
patent: 7919264 (2011-04-01), Maksymowych et al.
patent: 2002/0136719 (2002-09-01), Shenoy et al.
patent: 2003/0012786 (2003-01-01), Teoh et al.
patent: 2003/0049725 (2003-03-01), Heavner
patent: 2003/0161828 (2003-08-01), Abdelghany et al.
patent: 2003/0206898 (2003-11-01), Fischkoff et al.
patent: 2003/0219438 (2003-11-01), Salfeld et al.
patent: 2003/0235585 (2003-12-01), Fischkoff et al.
patent: 2004/0009172 (2004-01-01), Fischkoff et al.
patent: 2004/0033228 (2004-02-01), Krause et al.
patent: 2004/0120952 (2004-06-01), Knight
patent: 2004/0126372 (2004-07-01), Banerjee et al.
patent: 2004/0126373 (2004-07-01), Banerjee et al.
patent: 2004/0131614 (2004-07-01), Banerjee et al.
patent: 2004/0136989 (2004-07-01), Banerjee et al.
patent: 2004/0136990 (2004-07-01), Banerjee et al.
patent: 2004/0136991 (2004-07-01), Banerjee et al.
patent: 2004/0151722 (2004-08-01), Banerjee et al.
patent: 2004/0166111 (2004-08-01), Kaymakcalan et al.
patent: 2004/0219142 (2004-11-01), Banerjee et al.
patent: 2005/0019794 (2005-01-01), Nassef et al.
patent: 2005/0123541 (2005-06-01), Heavner
patent: 2005/0249735 (2005-11-01), Le
patent: 2006/0009385 (2006-01-01), Hoffman et al.
patent: 2006/0018907 (2006-01-01), Le
patent: 2006/0083741 (2006-04-01), Hoffman et al.
patent: 2006/0153846 (2006-07-01), Krause et al.
patent: 2006/0246073 (2006-11-01), Knight
patent: 2007/0003548 (2007-01-01), Heavner
patent: 2007/0041905 (2007-02-01), Hoffman et al.
patent: 2007/0071747 (2007-03-01), Hoffman et al.
patent: 2007/0081996 (2007-04-01), Hoffman et al.
patent: 2007/0172897 (2007-07-01), Maksymowych et al.
patent: 2007/0196373 (2007-08-01), Le
patent: 2007/0202104 (2007-08-01), Banerjee et al.
patent: 2007/0292442 (2007-12-01), Wan et al.
patent: 2007/0298040 (2007-12-01), Le
patent: 2008/0025976 (2008-01-01), Le
patent: 2008/0118496 (2008-05-01), Medich et al.
patent: 2008/0131374 (2008-06-01), Medich et al.
patent: 2008/0166348 (2008-07-01), Kupper et al.
patent: 2008/0193466 (2008-08-01), Banerjee et al.
patent: 2008/0227136 (2008-09-01), Pla et al.
patent: 2008/0292642 (2008-11-01), Borhani et al.
patent: 2008/0311043 (2008-12-01), Hoffman et al.
patent: 2009/0017472 (2009-01-01), Stuhlmuller et al.
patent: 2009/0028794 (2009-01-01), Medich et al.
patent: 2009/0110679 (2009-04-01), Li et al.
patent: 2009/0123378 (2009-05-01), Wong et al.
patent: 2009/0148513 (2009-06-01), Fraunhofer et al.
patent: 2009/0155205 (2009-06-01), Salfeld et al.
patent: 2009/0202557 (2009-08-01), Argiriadi et al.
patent: 2009/0226530 (2009-09-01), Lassner et al.
patent: 2009/0239259 (2009-09-01), Hsieh et al.
patent: 2009/0258018 (2009-10-01), Medich et al.
patent: 2009/0271164 (2009-10-01), Peng et al.
patent: 2009/0280065 (2009-11-01), Willian et al.
patent: 2009/0291062 (2009-11-01), Fraunhofer et al.
patent: 2009/0304682 (2009-12-01), Hoffman et al.
patent: 2009/0317399 (2009-12-01), Pollack et al.
patent: 2010/0003243 (2010-01-01), Okun et al.
patent: 2010/0016557 (2010-01-01), Salfeld et al.
patent: 2010/0021451 (2010-01-01), Wong et al.
patent: 2010/0040604 (2010-02-01), Salfeld et al.
patent: 2010/0040630 (2010-02-01), Elden et al.
patent: 2010/0160894 (2010-06-01), Julian et al.
patent: 2010/0278822 (2010-11-01), Fraunhofer et al.
patent: 2011/0002935 (2011-01-01), Wan et al.
patent: 2011/0054414 (2011-03-01), Shang et al.
patent: WO 97/29131 (1997-08-01), None
patent: WO 02/12502 (2002-02-01), None
patent: WO 02/072636 (2002-09-01), None
patent: WO 2004/009776 (2004-02-01), None
patent: WO 2005/121177 (2005-12-01), None
patent: WO 2006/012500 (2006-02-01), None
patent: WO 2006/069036 (2006-06-01), None
patent: WO 2008/121301 (2008-10-01), None
patent: WO 2009/020654 (2009-02-01), None
McPherson, A. Current Approaches to Macromolecular Crystallization. European Journal of Biochemistry. 1990. vol. 189, pp. 1-23.
Kundrot, C.E. Which Strategy for a Protein Crystallization Project? Cellular Molecular Life Science. 2004. vol. 61, pp. 525-536.
Benevenuti et al., Crystallization of Soluble Proteins in Vapor Diffusion for X-ray Crystallography, Nature Protocols, published on-line Jun. 28, 2007, 2(7):1633-1651.
Cudney R. Protein Crystallization and Dumb Luck. The Rigaku Journal. 1999. vol. 16, No. 1, pp. 1-7.
Drenth, “Principles of Protein X-Ray Crystallography”, 2nd Edition, 1999 Springer-Verlag New York Inc., Chapter 1, p. 1-21.
Ahamed et al. Phase Behaviour of Intact Monoclonal Antibody. Biochemical Journal, Jul. 2007, vol. 93, pp. 610-619.
Baldock, “A comparison of microbatch and vapour diffusion for initial screening of crystallization conditions,”Journal of Crystal Growth, Oct. 1996, vol. 168, No. 1-4, pp. 170-174 (abstact only).
Data Sheet: Drum Rollers—Portable Drum Rotators Drum Mixers, URL<:http://web.archive.org/web/20070117013405/http://www.morsemfgeo.com/products/201-Portable-Drum-Roller.htm>., Jan. 2007 [retrieved on Dec. 2, 2008].
Data Sheet: Fisher Scientific• Hematology/Chemistry Mixer Fisher Scientific, http://www.fishersci.com/, 2008 [Retrieved on Dec. 2, 2008].
Jen et al., “Diamonds in the Rough: Protein Crytsals from a Formulation Perspective,”Pharmaceutical Research, 2001, vol. 18, No. 11, pp. 1483-1488.
McPherson, “A comparison of salts for the crystallization of macromolecules,”Protein Science, 2001, vol. 10, pp. 418-422.
Yang et al., “Crystalline Monoclonal Antibodies for Subcutaneous Delivery,”Proceedings of the National Academy of SciencesJun. 10, 2003. vol. 100, No. 12, pp. 6934-6939.
Baldock, “A comparison of microbatch and vapour diffusion for initial screening of crystallization conditions,”Journal of Crystal Growth, Oct. 1996, vol. 168, No. 1-4, pp. 170-174.
Connell, G. E., et al., “A Human IgG Myeloma Protein Crystallizing with Rhombohedral Symmetry,” Can. J. Biochem., 1973, vol. 51, pp. 1137-1141.
Harris, L. J., et al., “The Three-dimensional Structure of an Intact Monoclonal Antibody for Canine Lymphoma,” Nature, 1992, vol. 360, pp. 369-372.
Huber, R., et al., “Crystallographic Structure Studies of an IgG Molecule and an Fc Fragment,” Nature, 1976, vol. 264, pp. 415-420.
International Preliminary Report on Patentability for Application No. PCT/US08/04006, dated Aug. 28, 2009.
International Search Report for Application No. PCT/US09/000568, dated May 13, 2009.
International Search Report for Application No. PCT/US08/009549, dated Dec. 17, 2008.
International Search Report and Written Opinion for Application No. PCT/US08/04006, dated Jul. 2, 2008.
International Search Report for Application No. PCT/US07/022622, dated Sep. 4, 2008.
Jentoft, J. E., et al., “Characterization of a Human Cryoglobulin Complex: A Crystalline Adduct of a Monoclonal Immunoglobulin G and Albumin,” Biocehmistry, 1982, vol. 21, pp. 289-294.
Jones, H. B., “On a New Substance Occurring in the Urine of a Patient with Mollities Ossium,” Phil. Tr. Royal Soc. London, 1848, vol. 138, pp. 55-62.
Mills, L. E., et al., “Crystallocryoglobulinemia Resulting from Human Monoclonal Anti
Borhani David W.
Fraunhofer Wolfgang
Gottschalk Stefan
Koenigsdorfer Anette
Krause Hans-Juergen
Abbott Biotechnology Ltd.
Cowles Cristin
McCarter & English LLP
Noakes Suzanne M
LandOfFree
Crystalline anti-hTNFalpha antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Crystalline anti-hTNFalpha antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystalline anti-hTNFalpha antibodies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4292323