Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
1993-07-29
1995-06-13
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
558166, C07F 9165
Patent
active
054244714
ABSTRACT:
The present invention relates to a sterile, stable vacuum dried crystalline amifostine composition and, optionally, pharmaceutically acceptable excipient(s). Typically, the crystalline compositions of the present invention exhibit enhanced stability at temperatures ranging from about 4.degree. C. to about ambient temperature for a period of at least 2 years relative to existing solid vacuum dried amorphous amifostine preparations. The reconstituted compositions of the present invention are suitable for administration to humans as a radio- or chemoprotecting agent.
REFERENCES:
patent: 3892824 (1975-07-01), Piper et al.
patent: 4424216 (1984-01-01), Cerami et al.
Eichler et al. "Radiation Inactivation Analysis of Enzymes" J. Biol. Chem. 1984, 262(20) 9433-9436.
Starke and Farber, "Ferric Iron and Superoxide Ions are Required for the Killing of Cultured Hepatocytes by Hydrogen Peroxide", J. Biol. Chem. 1985, 260(18), 10099.
Geary et al., "Characterization of Ethiofos Absorption in the Rat Small Intestine", Biopharmaceutics & Drug Disposition 1991, 12, 261-274.
Geary et al., "Characterization of WR-1065 Absorption in the Rat Small Intestine", Biopharmaceutics & Drug Disposition 1991, 12 75-284.
Zadeii et al., "Stability of Ethiofos (NSC-29691) in Aqueous Solution and Solid Phase Formulation", Pharm. Res. (NY) 1991, 8(10 Suppl.):S172.
Treskes et al., "Time Dependence of the Selective Modulation of Cisplaxin-induced Nephrotoxicity by WR 2721 in the Mouse", Cancer Res. 1992, 52, 2257-2260.
Karle JM et al. "Structure of the Radiation Protection Agent S-2(3-Aminopropylamino)ethylphosphorothioic Acid (WR 2721)." Acta Cryst. (1988). C44, 135-138.
Baldoni John M.
Kennedy Paul E.
Rajewski Roger A.
Ambrose Michael G.
Lee Mary C.
U.S. Bioscience, Inc.
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