Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-05-23
1996-09-17
Rizzo, Nicholas
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540222, C07D50132, A61K 31545
Patent
active
055568505
ABSTRACT:
The invention relates to crystalline acid addition salt of the two diastereomers of the 1-(2,2-dimethylpropionyloxy)ethyl 3-cephem-4-carboxylate of the general formula II ##STR1## in which X is the anion of a physiologically acceptable, mono- or polybasic, inorganic or organic acid and the group .dbd.N--OH is in the syn-position, pharmaceutical formulations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the use of the cephem derivatives for combating bacterial infections.
REFERENCES:
patent: Re34865 (1992-03-01), Adam et al.
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4203899 (1980-05-01), Ochiai et al.
patent: 4205180 (1980-05-01), Ochiai et al.
patent: 4264595 (1981-04-01), Numata et al.
patent: 4278793 (1981-07-01), D urckheimer et al.
patent: 4283396 (1981-08-01), Heymes et al.
patent: 4298606 (1981-11-01), Ochiai et al.
patent: 4355160 (1982-10-01), Ochiai et al.
patent: 4409215 (1983-10-01), Takaya et al.
patent: 4462999 (1984-07-01), Takaya et al.
patent: 4483855 (1984-11-01), Nakao et al.
patent: 4486425 (1984-12-01), Nakao et al.
patent: 4514565 (1985-04-01), Ochiai et al.
patent: 4668783 (1987-05-01), Ochiai et al.
patent: 4904652 (1990-02-01), Takaya et al.
patent: 4912212 (1990-03-01), Ochiai et al.
patent: 4973684 (1990-11-01), Ochiai et al.
patent: 4992431 (1991-02-01), Heymes et al.
patent: 5026695 (1991-06-01), Takaya et al.
patent: 5100887 (1992-03-01), Adam et al.
patent: 5409918 (1995-04-01), Adam et al.
T. Nishimura et al., Orally Active 1-(Cyclohexyloxycarbonyloxy)alkyl Ester Prodrugs of Cefotiam, XL J. Antibiotics 81-90 (1987).
K. Fujimoto et al., Studies on Orally Active Cephalosporin Esters, XL J. Antibiotics 370-384 (1987).
H. Kamachi et al., Synthesis and Biological Acitivity of a New Cephalosporin, BMY-28232 and its Prodrug-type Esters for Oral Use, XLI J. Antibiotics 1602-16 (1988).
E. Defossa et al., Cefdaloxime Pentexil Tosilate (HR 916 K): A Diastereomerically Pure Novel Oral Cephalosporinester: Synthesis and Antibacterial Actrivity In Vivo, Abstract No. 187, XXXII Interscience Conference on Antimicrobial Agents and Chemotherapy (Anaheim, CA, Oct. 11-14, 1991).
D. Isert et al., Cefdaloxine Pentexil Tosilate (HR 916 K): A Diastereomerically Pure Novel Oral Cephalosporinester With Outstanding Absorption Characteristics, Abstract No. 188, XXXII Interscience Conference on Antimicrobial Agents and Chemotherapy (Anaheim, CA, Oct. 11-14, 1991).
Defossa Elisabeth
Fischer Gerd
Isert Dieter
Jendralla Joachim-Heiner
Lattrell Rudolf
Hoechst Aktiengesellschaft
Rizzo Nicholas
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