Crystalline ACAT inhibitor

Details Crystalline ACAT inhibitor Crystalline ACAT inhibitor

2006-02-15

2009-11-24

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S616000

Reexamination Certificate

active

07622610

ABSTRACT:
The invention is directed to the Form A polymorph of N-benzyl-N′-(2,6-diisopropyl-phenyl)-N-isopropyl-malonamide and its use as a therapeutic/cosmetic agent.

REFERENCES:
patent: 4299845 (1981-11-01), Loebenberg et al.
patent: 6133326 (2000-10-01), Mayne
patent: 2005/0079144 (2005-04-01), Kostlan et al.
patent: 0 433 622 (1991-06-01), None
patent: WO 01/56556 (2001-08-01), None
Yagyu et al., Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia, Journal of Biological Chemistry, pp. 21324-21330, vol. 275/28, Jul. 2000.
Co-pending, commonly assigned U.S. Appl. No. 10/958,306, filed Oct. 5, 2004 and published as 2005-0079144A1 on Apr. 14, 2005.

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