Crystalline ACAT inhibitor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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Reexamination Certificate

active

07981936

ABSTRACT:
The invention is directed to the Form A polymorph of N-benzyl-N′-(2,6-diisopropyl-phenyl)-N-isopropyl-malonamide and its use as a therapeutic/cosmetic agent.

REFERENCES:
patent: 4299845 (1981-11-01), Loebenberg et al.
patent: 6133326 (2000-10-01), Mayne
patent: 2005/0079144 (2005-04-01), Kostlan et al.
patent: 0 433 622 (1991-06-01), None
patent: 0 699 439 (1996-03-01), None
patent: WO 01/56556 (2001-08-01), None
patent: WO 2005/035931 (2005-04-01), None
Yagyu et al.,Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia, Journal of Biological Chemistry, vol. 275/28, pp. 21324-21330.

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