Crystalline...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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Reexamination Certificate

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06965027

ABSTRACT:
This invention relates to novel amorphous and crystallline forms of 3-{(3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile mono citrate salt, useful as inhibitors of protein kinases, and to their methods of preparation.

REFERENCES:
patent: WO 9965908 (1999-12-01), None
patent: WO 99 65909 (1999-12-01), None
patent: WO 0142246 (2001-06-01), None
patent: WO 02/96909 (2002-12-01), None
Groom, Colin R. et al, Drug Discovery Today, vol. 7, No. 15, 2002, pp. 801-802.
Hong, J.C. et al, Semin. Nephrol., vol. 20, No. 2, 2000, pp. 1080125.
Malaviya, R. et al. Pharm. Exper. Therap., vol. 295, No. 3, 2000, pp. 912-926.
Aringer, M. et al, Life Sci., vol. 64, No. 24, 1999, pp. 2173-2186.
Wilcox, et al., U.S. Appl. No US 2003/0073719, Published Apr. 17, 2003.
Blumenkopl, et al., U.S. Pat. Appl. No. US 2001/0053782, Published Dec. 20, 2001.
Blumenkopl, et al., U.S. Appl. No. US 2004/0053947, Published Mar 18, 2004.
Wilcox, et al., U.S. Pat,. Appl. No. 10/869,101, filed Jun. 15, 2004 (continuation of U.S. Pat. Appl. No. US 2003/0073719, published Apr. 17, 2003).

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