Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2006-08-01
2006-08-01
Prats, Francisco C. (Department: 1651)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S183000, C536S028700
Reexamination Certificate
active
07083961
ABSTRACT:
The invention provides a crystalline complex containingT. foetusIMPDH in complex with inosine monophosphate (IMP), the complex specified by disclosed atomic coordinates. Also provided are crystalline complexes of containingT. foetusIMPDH with both inosine monophosphate (IMP) and mycophenolic acid, with both xanthosine monophosphate (XMP) and mycophenolic acid, with both xanthosine monophosphate (XMP) and nicotinic adenine dinucleotide (NAD), with ribovirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, and with both ribovirin and mycophenolic acid, each complex specified by disclosed atomic coordinates. Also provided by the invention are the atomic coordinates for these complexes. Further provided by the invention are methods for identifying modulations of IMPDH that employ the atomic coordinates of the invention.
REFERENCES:
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Luecke Hartmut
Prosise Glen
Fernandez Susan E.
McDermott & Will & Emery
Prats Francisco C.
Regents of the University of California
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