Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-04-05
2011-04-05
Jiang, Shaojia Anna (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S124000, C514S023000
Reexamination Certificate
active
07919598
ABSTRACT:
The present invention relates to physical crystal structures of a compound of the formula I:wherein R1, R2, R2a, R3and R4are as defined herein, especiallypharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
REFERENCES:
patent: 6414126 (2002-07-01), Ellsworth et al.
patent: 6515117 (2003-02-01), Ellsworth et al.
patent: 6774112 (2004-08-01), Gougoutas
patent: 2006/0063722 (2006-03-01), Washburn et al.
patent: 2007/0015841 (2007-01-01), Tawa et al.
patent: 0997472 (2000-05-01), None
patent: WO 01/27128 (2001-04-01), None
patent: 02/083066 (2002-10-01), None
patent: 2004/063209 (2004-07-01), None
definition of solvate, The Free Online Dictionary, http://www.thefreedictionary.com/solvate, accessed online on Jul. 21, 2009.
Vippagunta et al. Advanced Drug Delivery Reviews, 2001, 48, p. 3-26.
Morris et al. Advanced Drug Delivery Reviews, 2001, 48, p. 91-114.
Seddon et al. Crystal Engineering: the design and application of functional solids, 1999, Kluwer Academic Publishers, p. 69-78.
International Search Report, European Patent Office, mailed Oct. 31, 2007.
Slides from an oral presentation given at Princeton University on Sep. 4, 2008.
Wei Meng et al., Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes, J. Med. 2008, pp. 1145-1149, vol. 51.
Prashant P. Deshpande et al., Remarkable beta-selectivity in the Synthesis of beta-1-C-Arylglucosides: Stereoselective Reduction of Acetyl-Protected Methyl 1-C-Arylglucosided without Acetoxy-Group Participation, J. Org. Chem. 2007, pp. 9746-9749, vol. 72.
Greene, T.W. et al., “Protective Groups in Organic Synthesis”, Third Edition, John Wiley & Sons, Inc. (1999).
Johannson, G. et al, “Growth Hormone Treatment of Abdominally Obese Men Reduces Abdominal Fat Mass Glucose and Lipoprotein Metabolism and Reduces Diastolic Blood Pressure”, Journal of Clinical Endocrinology and Metabolism, vol. 82, No. 3, pp. 727-734 (1997).
Kuribayashi, T. et al., “AgOTfa/SnCl4: A Powerful New Promoter Combination in the Aryl C-Glycosidation of a Diverse Range of Sugar Acetates and Aromatic Substrates”, Tetrahedron Letters vol. 39, pp. 4537-4540, (1998).
Kuribayashi, T. et al, “C-Glycosylated Diphenylmethanes and Benzophenones: The Stille Coupling Reaction of C-Glycosylated Aryl Tins With Benzyl Bromides and Acid Chlorides”, J.Carbohydrate Chemistry, 18(4), pp. 393-401, (1999).
Anthony G. M. Barrett et al., Total Synthesis of the Antifungal Agent Papulacandin D, J. Chem. Soc., Chem. Commun., 1995, pp. 1147-1148.
Anthony G. M. Barrett et al., Total Synthesis and Structural Elucidation of the Antifungal Agent Papulacandin D, J. Org. Chem., 1996, pp. 1082-1100, vol. 61.
Vincente Lecomte et al., Improved Addition of Phenyllithium to Hindered Ketones by the use of Non-polar Media, Tetrahedron Letters, 2002, pp. 3463-3465, vol. 43.
Vincente Lecomte et al., Improved Addition of Organolithium Reagents to Hindered and/or Enolissable Ketones, Tetrahedron, 2003, pp. 2169-2176, vol. 59.
Bien Jeffrey T.
Deshpande Prashant P.
DiMarco John D.
Gougoutas Jack Z.
Grosso John Anthony
Bristol--Myers Squibb Company
Jiang Shaojia Anna
Lau Jonathan S
McDonnell Boehnen & Hulbert & Berghoff LLP
LandOfFree
Crystal structures of SGLT2 inhibitors and processes for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Crystal structures of SGLT2 inhibitors and processes for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystal structures of SGLT2 inhibitors and processes for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2732791