Crystal structure of TGF-.beta.-2

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

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530324, A61K 3700

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053229339

ABSTRACT:
A composition of crystalline TGF-.beta.2 is described. The tertiary structure of the protein homodimer determined by X-ray crystallography to 2.1 angstrom resolution is shown. This structure provides data useful in the rational design of drugs to mimic the physiologic properties of proteins of the TGF-.beta. family.

REFERENCES:
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4627982 (1986-12-01), Seyedin et al.
patent: 4760131 (1988-07-01), Sundsmo et al.
patent: 4774228 (1988-09-01), Seyedin et al.
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4806523 (1989-02-01), Bentz et al.
patent: 4810691 (1989-03-01), Seyedin et al.
patent: 4816442 (1989-03-01), McPherson et al.
patent: 4843063 (1989-06-01), Seyedin et al.
patent: 4950483 (1990-08-01), Ksander et al.
patent: 4971952 (1990-11-01), Bentz et al.
patent: 5008240 (1991-04-01), Bentz et al.
patent: 5024841 (1991-06-01), Chu et al.
Abstract, F. Inagaki, Cell Struct. Funct., Oct. 1990, 15 (5), pp. 237-243.
Abstract, M. P. Schlunegger et al, Nature, Jul. 30, 1992, 358 (6385), pp. 430-434.
Abstract, M. P. Schlunegger et al, FEBS Lett, May 25, 1992, 303 (1), pp. 91-93.
Abstract, A. T. Danishefsky et al, Biochem. Biophys, Res. Commun., Aug. 31, 1992, 187 (1), pp. 146-151.
Gilliland Meth Enzymol 104, 370 1984.
Schlunegger et al. Experientia 48, A418, 1992.

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