Crystal structure of cysteine protease

Details Crystal structure of cysteine protease Crystal structure of cysteine protease

2006-05-30

2006-05-30

Celsa, Bennett (Department: 1639)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S226000, C530S333000, C530S350000

Reexamination Certificate

active

07052851

ABSTRACT:
The present invention relates to the death protease CPP32 in crystallized form and a method for the preparation thereof. The invention further provides a three-dimensional model of CPP32 and improved means for the design of CPP32 modulators.

REFERENCES:
patent: 5834228 (1998-11-01), Becker et al.
patent: 95/35367 (1995-12-01), None
patent: 97/31018 (1997-08-01), None
Wang et al., J. Biol. Chem. vol. 270, No. 30 pp. 18044-18050 (Jul. 1995).
Nicholson, D.W., Nature 376, 37-43 (1995).
Casciola-Rosen, L.A. et al., J. Biol. Chem. 269, 30757-30760 (1994).
Bernstein, F.C. et al., J. Mol. Biol. 112: 535-542 (1977).
Fernandes-Alnemci, T. et al., J. Biol. Chem. 269, 30761-30764 (1994).
Travis, J., Science 262, 1374 (1993).
Meng, E.C. et al., J. Comp. Chem. 13, 505-524 (1992).
Thornberry et al., Nature 356—768-774 (1992).
Jones, T.A. et al., EMBO Journal 5, 819-822 (1986).
Ponder, J.W. et al., J. Mol. Biol. 193, 775-791 (1987).
Brunger, A.T. et al., Science 235—458-460 (1987).
Navazo, J., Acta Cryst. D50, 157-163 (1994).
Jones, T., et al., Acta Cryst. A47, 110-119 (1991).
Litwack, et al., (Jeffereson University) U.S. Appl. No. 446,927, filed Jun. 18, 1995.
Wilson, K., et al., Nature 370, 270-274 (1994).
Rotonda, J., et al., Nature Structural Biology 3, 619-625 (1996).
Nicholson, D.W., Nature Biotechnology 14, 297-301 (1996).
Sali, A., Current Opinion in Biotechnology 6, 437-451 (1995).
Casciola-Rosen et al., J. Exp. Med., vol. 183—1957-1964, May 1996.
International Search Report, Feb. 3, 1998.
Mittle et al., The Journal of Biological Chemistry, vol. 272, No. 10, 6539-6547, 1997.
Walker et al., Cell, vol. 78—343-352, Jul. 29, 1994 (No translation).
Protein Crystallography; T. L. Blundell and L. N. Johnson; 1976 Academic Press; p. 94, Table 411.

Affiliated with

Also associated with

Rating

Crystal structure of cysteine protease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystal structure of cysteine protease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystal structure of cysteine protease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3553445