Crystal structure of CRIg and C3b:CRIg complex

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical

Reexamination Certificate

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C703S011000, C435S183000, C436S004000

Reexamination Certificate

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07930109

ABSTRACT:
The present invention concerns determination of the crystal structure of the macrophage specific receptor, CRIg (earlier referred to as STIgMA), and its complex with the C3b and C3c subunits of complement C3 (C3b:CRIg and C3c:CRIg complexes). The invention further concerns the use of the crystal structure of CRIg or the C3b:CRIg complex to screen for and identify molecules structurally and/or functionally related to CRIg, including CRIg agonists and antagonists.

REFERENCES:
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patent: WO 2006/042329 (2006-04-01), None
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Benvenuti, et al., “Crystallization of soluable proteins in vapor diffusion for x-ray crystallography”, Nature Protocols, published online, 2(7): 1633-1651, (2007).
Cudney, “Protein crystallization and dumb luck”, The Rigaku Journal, vol. 16, No. 1, pp. 1-7, (1999).
Drenth, “Principlesof protein x-ray crystallography”, 2ndEdition, Chapter 1, pp. 1-21, (1999).

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