Crystal structure of aurora a kinase and uses thereof

Details Crystal structure of aurora a kinase and uses thereof Crystal structure of aurora a kinase and uses thereof

2007-05-08

2007-05-08

Kerri, Kathleen M. (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Reexamination Certificate

active

10491854

ABSTRACT:
The invention provides crystalline forms of a polypeptide corresponding to the catalytic domain of Aurora kinase. The active site ATP binding pocket is defined by its amino acid residues and their atomic coordinates. This structure may be used to select or design chemical modulators of Aurora kinase, particularly Aurora inhibitors. These modulators may be used to treat diseases of cell proliferation, e.g. cancer.

REFERENCES:
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patent: 1522580 (2005-04-01), None
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