Data processing: structural design – modeling – simulation – and em – Simulating nonelectrical device or system – Biological or biochemical
Reexamination Certificate
2008-02-13
2010-10-05
Noakes, Suzanne M. (Department: 1656)
Data processing: structural design, modeling, simulation, and em
Simulating nonelectrical device or system
Biological or biochemical
C435S194000
Reexamination Certificate
active
07809541
ABSTRACT:
The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
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Szklarz and Halpert, ȁ
Cheetham Graham
Coll Joyce T.
Knegtel Ronald
Renwick Suzanne
Swenson Lovorka
Doss Raymond M.
Haley Jr. James F.
Noakes Suzanne M.
Ropes & Gray LLP
Vertex Pharmaceuticals Incorporated
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