Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1995-05-25
1999-01-05
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 24, 435212, 435219, 435226, C12Q 137
Patent
active
058561161
ABSTRACT:
Interleukin-1.beta. converting enzyme ("ICE") processes an inactive precursor to the pro-inflammatory cytokine, interleukin-1.beta.. The high-resolution structure of human ICE crystallized in complex with an inhibitor is determined by X-ray diffraction. The active site spans both the 10 and 20 kilodalton subunits. The accessory binding site is composed of residues from the p10 and p20 subunits that are adjacent to the two-fold axis of the crystal. The structure coordinates of the enzyme may be used to design novel classes of ICE inhibitors.
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Griffith James P.
Kim Eunice E.
Livingston David J.
Wilson Keith P.
Dixon Lisa A.
Haley, Jr. Esq. James F.
Nashed Nashaat T.
Vertex Pharmaceuticals Incorporated
Wax Robert A.
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