Crystal of the core portion of a signal transducer and activator

Details Crystal of the core portion of a signal transducer and activator Crystal of the core portion of a signal transducer and activator

1998-05-29

2000-12-12

Nashed, Nashaat T.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530418, 530420, C07K 1400, A23J 100

Patent

active

06160092&

ABSTRACT:
The present invention provides a crystal of the core portion of the STAT protein in dimeric form with an 18-mer duplex DNA that contains a binding site for the STAT-dimer. The crystal is of sufficient quality to perform X-ray crystallographic studies. Methods of preparing the crystals are include in the invention. The present invention further discloses the three-dimensional structure of the crystal. The present invention also provides methods of using the structural information in drug discovery and drug development.

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