Crystal of human glycoprotein VI collagen binding domain

Details Crystal of human glycoprotein VI collagen binding domain Crystal of human glycoprotein VI collagen binding domain

2007-03-28

2011-12-27

Steadman, David J (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

08084577

ABSTRACT:
A crystal comprising the collagen binding domain of human GPVI is provided and defined by structural atomic coordinates. Employing computer modeling based on the crystal structure, including methods for identifying inhibitors of GPVI collagen binding activity, methods for screening libraries of compounds for potential to bind to the GPVI collagen binding domain, and methods of identifying a compound useful for the treatment of a GPVI-mediated disorder, are also provided.

REFERENCES:
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Zheng et al, “Expression of the Platelet Receptor GPVI Confers Signaling via the Fc Receptor gamma-Chain in Response to the Snake Venom Convulxin but not to Collagen,” Journal of Biological Chemistry, 276(16): 12999-13006 (Apr. 30, 2001).
International Search Report for PCT/US07/07900, dated Sep. 2, 2008.
Romijn, R. Identification of the Collagen-binding Site of the von Willebrand Factor A3-domain, Journal of Biological Chemistry, 2001, vol. 276, pp. 9985-9991, especially p. 9987, Table 1.
Horii, K., et al. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood, 2006, vol. 108, pp. 936-942.

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