Crystal of beta-nicotinamide-adenine-dinucleotide and process fo

Details Crystal of beta-nicotinamide-adenine-dinucleotide and process fo Crystal of beta-nicotinamide-adenine-dinucleotide and process fo

1983-04-19

1985-05-07

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1920, C07H 2102

Patent

active

045159432

ABSTRACT:
Novel highly pure and stable crystals of .beta.-nicotinamide-adenine-dinucleotide tetrahydrate (NAD) which is triclinic system and has a space group of P1 or P1 and lattice constants: a=8.861 .ANG., b=11.181 .ANG., c=8.630 .ANG., .alpha.=90.82.degree., .beta.=103.40.degree. and .gamma.=109.71.degree.. The crystalline NAD is prepared by cooling a 20 to 60 w/v % aqueous solution of amorphous NAD, which has preferably been treated with a porous weakly basic anion exchange resin to remove impurities, at a temperature of 0.degree. to 20.degree. C. When the crystalline NAD is added to the aqueous solution as seeds, the desired high pure crystalline NAD is prepared without conducting the treatment of amorphous NAD with the porous weakly basic anion exchange resin. A high pure amorphous NAD is obtained from the crystalline NAD by dissolving the crystalline NAD in water and subjecting the aqueous solution to freeze drying or precipitation with a solvent.

REFERENCES:
patent: 3435026 (1969-03-01), Samejima et al.
patent: 3700654 (1972-10-01), Brusca
patent: 4148994 (1979-04-01), Muhlegger et al.
patent: 4151349 (1979-04-01), Traeger et al.
Winer; A., J. Biol. Chem., vol. 239, pp. 3598-3600, 1964.

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