Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1998-07-21
2000-12-05
Nashed, Nashaat
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435195, 530350, 702 19, 702 22, C12Q 134
Patent
active
061565261
ABSTRACT:
A detailed three-dimensional structure for the complex formed between Ras and the Son of sevenless (Sos) protein is provided. Crystals of this complex are also included in the invention. The present invention farther provides procedures for identifying agents that can inhibit tumor proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
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Bar-Sagi Dafna
Boriack-Sjodin Ann
Cole Philip
Kuriyan John
Margarit S. Mariana
Nashed Nashaat
The Research Foundation of State University of New York
The Rockerfeller University
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