Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-29
2011-03-29
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S537000
Reexamination Certificate
active
07915302
ABSTRACT:
The present invention provides novel crystalline forms D1and D2of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt, and hydrates thereof. The crystalline forms D1and D2have X-ray powder diffraction peaks described in FIGS.1and3, respectively. Further, the present invention provides processes for preparing the crystalline forms and pharmaceutical compositions comprising the crystalline forms. The crystalline forms can be produced on a commercial scale and exhibit excellent stability.
REFERENCES:
patent: 5273995 (1993-12-01), Roth
patent: 5969156 (1999-10-01), Briggs et al.
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.
Vippagunta et al., abstract, Vippagunta, Sudha R. “Crystalline Solids.” Advanced Drug Delivery Reviews 48(2001): 3-26.
Cha Dae Won
Choi Jun Ho
Kim Moon Sung
Kim Yong Jik
Lim Hong Gyu
Anderson Rebecca L
Dong-A Pharm. Co., Ltd.
Goldberg Joshua B.
Koh Mihsuhn
Shterengarts Samantha L
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