Crystal forms of lamotrigine and processes for their...

Details Crystal forms of lamotrigine and processes for their... Crystal forms of lamotrigine and processes for their...

2005-03-01

2005-03-01

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S182000

Reexamination Certificate

active

06861426

ABSTRACT:
The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal forms of lamotrigine.

REFERENCES:
patent: 4560687 (1985-12-01), Baxter et al.
patent: 6124308 (2000-09-01), Nobbs et al.
Janes et al., “Structure of Lamotrigine Methanol Solvate: 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine-Methanol, a Novel Anticonvulsant Drug,” Acta Cryst., 1989, C45, 129-132.
Pharmacopeial Forum, vol. 24, No. 1, (Jan.-Feb. 1998) p. 5438-5440.
E. Schmitt et al “Moisture-Dependent Crystallization of Amorphous Lamotrigine Mesylate” Journal of Pharmaceutical Sciences vol. 85, No. 11, Nov. 1996, pp. 1215-1219.

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