Crystal forms of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S201000

Reexamination Certificate

active

07825138

ABSTRACT:
Crystalline polymorphs of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.

REFERENCES:
patent: 6303620 (2001-10-01), Hansen et al.
patent: 6576648 (2003-06-01), Ankersen
patent: 2001/0041720 (2001-11-01), Ankersen
Seddon “Pseudomorph . . . ” Crystal growth and design v.4(6)p. 1087(2004)(p. 1-2 internet print).
Bennett “chemical dictionary” p. 553 (1976).
Niazi “hnadbook of . . . ” (2009) ( one page from internet).
Seddon “Pseudopolymorph . . . ” Crystal growth & design v. 4(6) p. 1087 (2004) (2 page from internet).
Bernstein “Polymorphism in molecular crystals” p. 115-118, 272 (2002).
Kirk-Othmer “Encyclopedia of chemical technology” p. 95-147 (2002).
Cheronis “Semimicro experimental organic chemistry” p. 31-43 (1958).
Fujiwara et al. “First principles and direct design . . . ” J. Process control v.15, p. 493-504 (2005).
Borchardt et al. “Pharmaceutical profiling . . . ” p. 93-125 (2004).
International Search Report, PCT/US2005/022408, Nov. 2, 2005.

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