Crystal forms of...

Details Crystal forms of... Crystal forms of...

2007-07-24

2007-07-24

Keys, Rosalynd (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S444000, C562S445000

Reexamination Certificate

active

10510927

ABSTRACT:
New crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, also known asnateglinide, may be produced by dissolving nateglinide in any of its forms, including solvates, in an organic solvent to form a solution followed by precipitation of nateglinide from the solution, and isolating and drying the precipitated crystal form of nateglinide. The precipitation of nateglinide may be induced either by cooling the solution, or by addition of another solvent which is miscible with the first solvent but in which nateglinide is only poorly soluble, or by combination of the two. Depending on the solvent a specific crystal form of nateglinide may be obtained, e.g., the R′-type crystal form of nateglinide produced by the described method has a different melting point, infra red spectra and X-ray diffraction patterns from the previously known crystal forms of nateglinide.

REFERENCES:
patent: 5463116 (1995-10-01), Sumikawa et al.
patent: WO 03/022251 (2003-03-01), None
Gang, Guo-qiang, Qun-wei and Chong-quan, “A New Crystal Form of Nateglinide”,Acta Pharmaceutica Sinica, vol. 36, No. 7, pp. 532-534 (2001).

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