Crystal form of phenylamino pyrimidine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S242000, C544S323000

Reexamination Certificate

active

08067422

ABSTRACT:
The present invention relates to a particular form of the (3,5-bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide (formula I), processes for the preparation thereof, pharmaceutical compositions containing this crystal form, and their use as anti tumor agent in humans. The compound of formula I, also known as AN-019, is:

REFERENCES:
patent: WO 99/15164 (1999-04-01), None
patent: WO 2004/029038 (2004-04-01), None
patent: WO 2004/110452 (2004-12-01), None
patent: 2006/027795 (2006-03-01), None
patent: WO 2006/027795 (2006-03-01), None
Invitation to Pay Additional Fees with Partial International Search mailed Jul. 15, 2009.
Ogata et al. “Synthesis and Antiviral activity of sulphonamidobenzophenone oximes and sulphonamidobenzamides.”Journal of Medicinal Chemistry. vol. 29, No. 3. 1986. pp. 417-423.
Zimmermann et al. “Potent and selective inhibitors of the Abl-kinase: Phenylaminopyrimidine (PAP) derivatives.”Bioorganic and Medicinal Chemistry Letters. vol. 7, No. 2. 1997. pp. 187-192.
Schindler et al. “Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase.”Science. vol. 289, No. 5486. 2000. pp. 1938-1942.
Caira, M., “Crystalline Polymorphism of Organic Compounds,”Topics in Current Chemistry, vol. 198, pp. 163-208 (1998).
International Search Report and Written Opinion mailed Oct. 29, 2009.
Paquette, L. (Editor), “Tin(II) Chloride,”Encyclopedia of Reagents for Organic Synthesis, pp. 4892-4893 (1995).

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