Crystal form of asenapine maleate

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S416000

Reexamination Certificate

active

07741358

ABSTRACT:
The invention relates to an orthorhombic crystal form of compound trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz [2,3:6,7]oxepino[4,5-c]pyrrole (Z)-2-butenedioate, to methods for the preparation of this crystal form and to pharmaceutical compositions comprising an orthorhombic crystal form.

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Vader, J. et al., “The Syntheses of Radiolabelled Org 5222 and Its Main Metabolite Org 30526,” Journal of Labelled Compounds and Radiopharmaceuticals, vol. 34, No. 9 (1994) pp. 845-869.
De Boer, Th. et al., Org-5222 “Antipsychotic Dopamine D2Receptor Antagonist 5-HT2Receptor Antagonist,” Drugs of the Future, vol. 18, No. 12 (1993) pp. 1117-1123.
Funke, C. W. et al., “Physico-chemical Properties and Stability of trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine Maleate,” Arzneim.-Forsch./Drug Res., vol. 40, No. 5 (1990) pp. 536-539.

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