Crystal form of adefovir dipivoxil and its preparation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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C544S244000

Reexamination Certificate

active

07417036

ABSTRACT:
A new crystal form of adefovir dipivoxil {9-[2-[bis(pivaloyloxy)-methoxy]-phosphinyl]-methoxyl]-ethyl]-adenime} and its composition is disclosed, as is a method to prepare the crystal comprising placing adefovir dipivoxil in a round bottom flask, adding organic solvent and dissolivng adefovir dipivoxil ultrasonically to form and adefovir dipivoxil solution, and spray drying the adefovir dipivoxil solution.

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patent: 5663159 (1997-09-01), Starrett et al.
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Barditch-Crovo P. et al., Journal of Infectious Diseases, 176 (2): 406, 1997.
Starrett et al., Journal of Med. Chem., 37: 1857-1864, 1994.

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