Crystal form of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S373000

Reexamination Certificate

active

07981897

ABSTRACT:
The present invention relates to a hitherto unknown crystal form B of (3-cyano-1H-indol-7-yl)-[4-(4-fluorophenethyl)-piperazin-1-yl]methanone, hydrochloride, to a process for the preparation thereof, and to the use thereof for the preparation of a medicament.

REFERENCES:
patent: 6838461 (2005-01-01), Boettcher et al.
patent: 7084143 (2006-08-01), Boettcher et al.
patent: 2005/0014766 (2005-01-01), van Amsterdam et al.
patent: WO 01/07435 (2001-02-01), None
patent: WO 02/059092 (2002-08-01), None
patent: WO 03/045392 (2004-04-01), None
Brittain “Polymorphism in Pharmaceutical Solids”, vol. 95, Drugs and Pharmaceutical Sciences, 1999.
Amamec R. et al., Prophylactic And Therapeutic Effects Of Acute Systemic Injections Of Emd 281014, A Selective Serotonin 2a Receptor Antagonist On Anxiety Induced By Predator Stress In Rats, European Journal of Pharmacology, Nov. 3, 2004, Amsterdam, NL.

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