Crystal form O of clarithromycin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 72, 536 185, A61K 3170, C07H 100, C07H 1708

Patent

active

059454059

ABSTRACT:
The present invention concerns the novel antiobiotic 6-O-methylerythromycin A form O solvate, a process for its preparation, pharmaceutical compositions comprising this compound and a method of use as a therapeutic agent.

REFERENCES:
patent: 4331803 (1982-05-01), Watanabe et al.
patent: 4670549 (1987-06-01), Morimoto et al.
patent: 4672109 (1987-06-01), Watanabe et al.
patent: 4808411 (1989-02-01), Lu et al.
patent: 4990602 (1991-02-01), Morimoto et al
patent: 5556839 (1996-09-01), Greene et al.
Acta Crystalographica Section C. Crystal Structure Communications, vol. C49, No. 5 (May 1993), pp. 1227-1230, Iwaskai et al., "Structure of 6-O-Methylerythromycin A (Clarithromycin)".
Journal of Antibiotics, vol. XLII, No. 6 (Jun. 1989), pp. 1012-1014, Takashi Adachi et al., "Crystal and Molecular Structure of (14R)-14-Hydroxy-6-O-Methylerythromycin A".
Cremer et al., Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 1995, 22, 732-33.

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