Crystal form and pharmaceutical compositions of (+)-R-zileuton

Details Crystal form and pharmaceutical compositions of (+)-R-zileuton Crystal form and pharmaceutical compositions of (+)-R-zileuton

2011-08-23

2011-08-23

Thomas, Timothy (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S058000

Reexamination Certificate

active

08003684

ABSTRACT:
Crystalline forms of (+)-R-zileuton, which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of (+)-R-zileuton are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline (+)-R-zileuton, and using it to inhibit 5-lipoxygenase activity in subjects to treat a number of diseases, are also discussed.

REFERENCES:
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Chang, Zui Lin, “Zileuton,”Analytical Profiles of Drug Substances and Excipients25:535-575 (1998).
Cotta Ramusino, M., et al., “1H NMR, UV and Circular Dichroism Study of Inclusion Complex Formation Between the 5-Lipoxygenase Inhibitor Zileuton and β- and γ-Cyclodextrins,”Journal of Inclusion Phenomena and Molecular Recognition in Chemistry32:485-498 (1998).
Galeazzi, E., et al., “A Congener Study of Zileuton Reveals Interesting Effects on Glucuronidation Rates,”Bioorganic&Medicinal Chemistry Letters4(12):1437-1442 (1994).
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