Crystal comprising (2R)-2-propyloctanoic acid and amine

Details Crystal comprising (2R)-2-propyloctanoic acid and amine Crystal comprising (2R)-2-propyloctanoic acid and amine

2005-04-27

2010-10-26

Zucker, Paul A (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C554S103000, C562S401000

Reexamination Certificate

active

07820715

ABSTRACT:
Crystals comprising (2R)-2-propyloctoic acid and an amine which retain the pharmacological effect of (2R)-2-propyloctoic acid and can be safely used as a medicinal raw drug for peroral solid preparations. Of these crystals, the crystals especially with dibenzylamine are advantageous because not only the crystals themselves are useful as a medicinal raw drug but also use of the crystals as an intermediate can yield (2R)-2-propyloctoic acid having an optical purity exceeding 99.5% e.e., which has not been obtained hitherto.

REFERENCES:
patent: 08291106 (1995-11-01), None
patent: 8-291106 (1996-11-01), None
patent: WO 00/48982 (2000-08-01), None
patent: WO 03/051852 (2003-06-01), None

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