Crystal and process for producing the same

Details Crystal and process for producing the same Crystal and process for producing the same

2006-06-27

2006-06-27

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S252000, C548S253000, C558S414000

Reexamination Certificate

active

07067546

ABSTRACT:
A process for producing crystals of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimdazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.

REFERENCES:
patent: 5196444 (1993-03-01), Naka et al.
patent: 6177587 (2001-01-01), Hashimoto et al.
John McMurray, Organic Chemistry, 1988, Brooks/Cole Publishing Company, 2ndEdiction, p. 355.
Kubo et al., “Nonpeptide Angiotensin II Receptor Antagonists. Synthesis and Biological Activity of Benzimidazolecarboxylic Acids” J. Med. chem. 36(15):2182-2195(1993).
Matsunaga, et al. “Solid-State Characterization of Candesartan Cilexetil (TCV-116): Crystal Structure and Moleuclar Mobility:” Chem. Pharm. Bull. 47(2) 182-186 (1999).

Affiliated with

Also associated with

Rating

Crystal and process for producing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystal and process for producing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystal and process for producing the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3637170