Cryptosporidium parvum antigens, antibodies thereto and...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S350000, C435S975000, C424S184100

Reexamination Certificate

active

10948490

ABSTRACT:
Cloning and expression of genes encodingC. parvumantigenic polypeptides are described as are antibodies that recognize epitopes on these polypeptides. The antigenic polypeptides and antibodies thereto can be used in therapeutic compositions for the prevention and treatment ofC. parvuminfections, as well as in diagnostic methods for determining the presence ofC. parvuminfections.

REFERENCES:
patent: 5591434 (1997-01-01), Jenkins et al.
patent: 5643772 (1997-07-01), Petersen et al.
patent: 5773245 (1998-06-01), Wittrup et al.
patent: 6323020 (2001-11-01), Perryman et al.
patent: WO 98/07320 (1998-02-01), None
Arrowood et al., “Effect of Immune Colostrum and Orally Administered Antisporozoite Monoclonal Antibodies on the Outcome ofCryptosporidium parvumInfections in neonatal Mice,”Infect. Immun. 57.(8):2283-2288 (1989).
Bjorneby et al., “Monoclonal Antibody Immunotherapy in Nude Mice Persistently Infected withCryptosporidium parvum,”Infect. Immun. 59(3):1172-1176 (1993).
Campbell et al., “Demonstration of Serum Antibodies toCryptospridiumsp. In Normal and Immunodeficient Humans with Confirmed Infections,”Journal of Clinical Microbiology 18(1):165-169 (1983).
Doyle et al., “Anti-Cryptosporidium parvumAntibodies Inhibit Infectivity In Vitro and In Vivo,”Infect. Immun. 61:4079-4084 (1993).
Jenkins et al., “Cloning and Expression of a cDNA Encoding Epitopes Shared by 15-and 60-Kilodalton Proteins ofCryptosporidium parvumSporozoites,”Infection and Immunity 61(6):2377-2382 (1993).
Jenkins et al., “Cloning and Expresson of cDanA Encoding an AntigenicCryptosporidium parvumProtein,”Molecular and Biochemical Parasitology 71:149-152 (1995).
Lillehoj et al., “CD8+T Cell-Coccidia Interactions,”Parasitology Today 10:10-16 (1994).
McDonald et al., “Localization of Parasite Antigens inCryptosporidium parvum-Infected Epithelial Cells Using Monoclonal Antibodies,”Parasitology 110:259-268 (1995).
Mead, J.R. et al., “Antigens ofCryptosporidiumSporozoites Recognized by Immune Sera of Infected Animals and Humans,”Journal of Parasitology 74(1):135-143 (1988).
Nina et al., “Analysis of Oocyst Wall and Sporozoite Antigens from ThreeCryptosporidiumSpecies,”Infection and Immunity 60(4):1509-1513 (1992).
Nord et al., “Treatment of AID Associated Cryptosporidiosis With Hyperimmune Colostrum From Cows Vaccinated withCryptosporidium,” Fifth International Conference on Aids, Montreal, Quebec, May 1989.
Ortega-Mora et al., “Cross-Reactivity of Polyclonal Serum Antibodies Generated AgainstCryptosporidium parvumOocyst,”Infection and Immununity 60(8):3442-3445 (1992).
Peeters et al., “Cryptosporidium parvumin Calves: Kinetics and Immunoblot Analysis of Specific Serum and Local Antibody Reponses (Immunoglobulin A [IgA], IgG, and IgM) After Natural and Experimental Infections,”Infection and Immunity 60(6):2309-2316 (1992).
Peterson et al., “Identification and Initial characterization FiveCryptosporidium parvumSporozoite Antigen Genes,”Infection and Immunity 60(6):2343-2348 (1992).
Ranucci et al., “Characterization and Immunolocalization of aCryptosporidumProtein Containing Repeated Amino Acid Motifs,”Infection and Immunity 61(6):2347-2356 (1993).
Reperant, Jean-Michel et al., “Major Antigens ofCryptosporidium parvumRecognized by Serum Antibodies from Different Infected Animal Species and Man,”Veterinary Parasitology 55(1-2):1-13 (1994)
Riggs et al., “Neutralization-Sensitive Epitopes Are Exposed on the Surface of InfectiousCryptosporidium parvumSporozoites,”The Journal of Immunology 143(4):1340-1345.
Strong, W.B. et al., “Cloning and Sequence Analysis of a Highly PolymorphicCryptosporidium parvumGene Encoding a 60-Kilodalton Glycoprotein and Characterization of its 15-and 45-Kilodalton Ziote Surface Antigen Products,”Infection and Immunity, American Society for Microbiology, Washington, U.S. 68(7):4117-4134 (2000).
Tzipori et al., “Remission of Diarhoea due to cryptosporidiosis in an Immunodeficient Child Treated with Hyperimmune Bove Colostrum,”British Medical Journal 293:1276-1277 (1986).
Ungar et al., “Cessation ofCryptosporidium- Associated Diarrehea in an Acquired Immunodeficiency Syndrome Patient After Treatment With Hyperimmune Bovine Colostrum,”Gastroenterology 98:486-489 (1990).
Whitmire et al., “Characterization of Bovine Cellular and Serum Antibody Responses during Infection byCryptoporidium parvum,”Infection and Immunity 59(3):990-995 (1991).
Accession No. AF178459 “Neutralising Antigen 2 ofCryptosporidium parvumRecognised by Human Immune Sera,” XP002205089, Sep. 5, 2000.
Accession No. AF178460 “Neutralising Antigen 1 of C. Parvum Recognised by Human Immune Sera,” XP0021694444, Sep. 5, 2000.
Accession No. AQ411949 “CpG 0925A C[OPWAgDMA1 C. Parvum Genomic, Genomic Survey Sequence,” XP002205088, Mar. 25, 1999.
Accession No. AQ988925 “Cryptosporidium parvumGenomic Clone 25A1A08NE,” XP002194443, Feb. 3, 2000.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cryptosporidium parvum antigens, antibodies thereto and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cryptosporidium parvum antigens, antibodies thereto and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cryptosporidium parvum antigens, antibodies thereto and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3838748

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.