Cryptosporidium hybrid vector and transformed host cells

Details Cryptosporidium hybrid vector and transformed host cells Cryptosporidium hybrid vector and transformed host cells

1995-04-03

1997-07-01

Housel, James C.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352523, 536 237, 935 12, C12N 1500, C12N 120

Patent

active

056437722

ABSTRACT:
The invention comprises a Cryptosporidium hybrid vector comprising a regulatory DNA segment operably coupled to a DNA fragment encoding a polypeptide to which anti-Cryptosporidium antibodies specifically bind and transformed host cells comprising the hybrid vectors.

REFERENCES:
Doyle, P.S. et al. 1992. J. Cell. Biochem. Suppl. 16A, p. 146.
Reeves, C.D. et al. 1987. Gene vol. 52 pp. 257-266.
Dykstra, CC. et al. 1991. J. Protozool vol. 38(6) pp. 76S-78S (Abstract Only Provided).
Petersen, C., The Mature erythrocyte surface antigen of Plasmodium falciparum is not required for knobs or cytoadherence, Molecular and Biochemical Parasitology, 36:61-66, (1989).
Petersen, C., The gene product of the Plasmodium falciparum 11.1 locus is a protein larger than one megadalton, Molecular and biochemical Parasitology, 42:189-196, (1990).
Petersen, C., Identification and Initial Characterization of Five Cryptosporidium parvum Sporozoite Antigen Genes, Infection and Immunity, pp. 2343-2348, (Jun. 1992).
Petersen, C., Characterization of a >900,000-M.sub.r Cryptosporidium parvum Sporozoite Glycoprotein Recognized by Protective Hyperimmune Bovine Colostral Immunoglobulin, Infection and Immunity, pp. 5132-5138, (Dec. 1992).
Coppel, Ross, L., Antibody Screening of Expression Libraries, Methods in Molecular Biology, vol. 21: Protocols in Molecular Parasitology, Chapter 21, pp. 277-296, (1993).

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