Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-07
1999-09-21
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 11, 930270, 530317, A61K 3812, C07K 752
Patent
active
059554231
ABSTRACT:
A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.
REFERENCES:
Goodman & Gilman's "The Pharmacological Basis of Therapeutics" 6th Ed. (MacMillan Publishing 1980) pp. 1249-1255; 1738-1740.
Corbett Thomas H.
Golakoti Trimurtulu
Mooberry Susan L.
Moore Richard E.
Patterson Gregory M. L.
Celsa Bennett
Kim Stanley H.
Reiter Stephen E.
The University of Hawaii
Tsang Cecilia J.
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