Cryostatic microtome

Details Cryostatic microtome Cryostatic microtome

1996-08-01

1998-06-09

Rachuba, Maurina T.

Cutting

Processes

83 42, 83367, 83370, 839155, B26D 706

Patent

active

057619778

ABSTRACT:
A cryostatic microtome with an automatic approach of the preparation automatically stops the feed movement between the microtome knife and a frozen preparation towards each other upon a mechanical contact between the knife and the preparation. An electrical voltage of a few volts is applied between the microtome knife and the preparation. A small current which appears, due to the intrinsic conductivity of the preparation, upon mechanical contact between the preparation and the microtome knife, and a smaller voltage drop at the preparation resulting therefrom, is current amplified by means of a preamplifier connected as an impedance converter and subsequently measured. The feed movement between the preparation and the microtome knife is automatically stopped when the voltage at the amplifier output falls below a predefined threshold voltage. The preset threshold voltage is temperature dependent and is calculated by a control processor corresponding to the temperature of the cryostat, based on a function and function coefficients. The temperature dependence of the threshold voltage ensures a reliable and precise approach of the preparation throughout the entire temperature range usual in cryomicrotomy.

REFERENCES:
patent: 3667330 (1972-06-01), Kobernick
patent: 4484503 (1984-11-01), Sitte et al.
patent: 4967629 (1990-11-01), Behne
patent: 5226335 (1993-07-01), Sitte et al.
patent: 5282404 (1994-02-01), Leighton et al.
patent: 5461953 (1995-10-01), McCormick

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