Cryoprotective reagents in freeze-drying membranes

Details Cryoprotective reagents in freeze-drying membranes Cryoprotective reagents in freeze-drying membranes

1988-11-18

1990-06-05

Thexton, Matthew A.

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Coated or structually defined flake, particle, cell, strand,...

Particulate matter

264 41, 424533, 424450, 436829, 514971, 435 2, B01J 1302, A61K 3722, A61K 3514

Patent

active

049313614

ABSTRACT:
The ability of phosphoglyceride-containing membranes to withstand the disruptive effects of freezing, thawing, or freeze-drying is enhanced when treated with (a) a compound of the formula R-X-R.sub.1, wherein R is a lipid or lipophilic anchor, X is a hydrophilic linker group, and R.sub.1 is a polyalcohol or carbohydrate group, and (b) ascorbic acid.

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patent: 4766046 (1988-08-01), Abra et al.
patent: 4772471 (1988-09-01), Vanlerberghe et al.
patent: 4806343 (1989-02-01), Carpenter et al.
Intern. J. Pharm, vol. 33, G. J. Fransen et al., "Critical Parameters in Freezing of Liposomes", (1986), pp. 27-35.

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