Cryoglobulin separation

Details Cryoglobulin separation Cryoglobulin separation

1987-08-04

1990-04-10

Jones, W. Gary

Liquid purification or separation

Processes

Making an insoluble substance or accreting suspended...

2103216, 210472, 210515, 210539, 210782, 210789, 422101, 422102, 494 37, 604410, 424101, 530380, 530383, 530830, B01D 2126

Patent

active

049158473

ABSTRACT:
A set for the isolation of cryoprecipitate includes a hollow vessel with first and second ends and a tapered body extending to a narrow sump closing the second end, said sump enclosing a volume of approximately 2 to 5 percent of the volume of the hollow vessel. A port enters the vessel in the tapered body above the sump. In one embodiment, the vessel is formed of a rigid or semi-rigid material and the first end is closed by a cap containing a micro-porous filter for venting the vessel. In another or further embodiment, the sump has a tapered tip portion which may be sliced off to permit extrusion of the isolated cryoprecipitate by squeezing the vessel. In a different embodiment, the vessel contains an inner filter column, or bag with a filter matrix, accessible via an access port. Cellular material placed in the column is frozen, thawed and centrifuged to separate out antigen-free platelet growth factor with the cryoprecipitate.

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"Now the way is clear . . . with the Cutter Leukotrap Platelet Pooling System" Miles Laboratories (1985) CB-676.

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