Cryogenic storage system

Refrigeration – Portable – commodity-containing

Reexamination Certificate

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C062S045100

Reexamination Certificate

active

10864921

ABSTRACT:
The present invention provides devices and methods for the cryogenic storage of biological material. Devices of the invention are useful for storing material at a cryogenic temperature. The devices include a temperature chamber defined by a thermally-conductive container and at least one layer of thermal insulation surrounding the thermally-conductive container. Some embodiments utilize one or more heat sources thermally connected to the thermally conductive container. Other embodiments are arranged so that no net flow of heat occurs from the temperature chamber when the temperature chamber is at a set target temperature. Also provided are methods of using the devices.

REFERENCES:
patent: 3729946 (1973-05-01), Massey
patent: 4495782 (1985-01-01), Salour et al.
patent: 4559298 (1985-12-01), Fahy
patent: 4848093 (1989-07-01), Simmonds et al.
patent: 5174122 (1992-12-01), Levine
patent: 5217860 (1993-06-01), Fahy et al.
patent: 6167710 (2001-01-01), Cosman
Fahy, et al., “Physical problems with the vitrification of large biological systems,”Cryobiology27:492-510 (1990).
Baudot, et al., “Physical Vitrification of Rabbit Aortas without any Fracture,”Cryobiology43:375-376 (2001).

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