Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Reexamination Certificate
2005-01-25
2005-01-25
Low, Christopher S. F. (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
C530S350000, C530S387100, C514S008100, C514S002600, C514S012200, C536S023600, C435S320100, C435S252100, C435S325000
Reexamination Certificate
active
06846913
ABSTRACT:
Disclosed is an extract from Korean mistletoe KM-110, which is of immunity enhancement and activity against tumor metastasis and can be used as an adjuvant material for vaccines applicable for the induction of humoral and cell-mediated immunity. Also disclosed are its fractions, a protein fraction KM-AS, a lectin fraction KML-C, lectin components KML-IIU and KML-IIL, which both are further purified from lectin fraction KML-C, a protein KMHBP which is obtained through heparin binding chromatography eluting with NaCl from a fraction C-free AS which is a portion of the KM-AS free of KML-C, and a mixture KM of the KMHBP and the KML-C. They are revealed as to their roles in the humoral and cell-mediated immunity enhancement and antitumoral activity.
REFERENCES:
patent: 5565200 (1996-10-01), Khwaja
Khwaja et al. (Proc. Am. Assoc. Cancer Res. Annu. Meet. 28, 303 (1987)).*
Yoon et al., International J. Immunopharmacology 20, 163-172 (Apr.-May 1998).
Doo Myoungsool
Kang Taebong
Kim Jong-bae
Kwak Jinhwan
Lee Kwan-hee
Heiman Lee C.
Kam Chih-Min
Low Christopher S. F.
Mistle Biotech Co., Ltd.
Nath Gary M.
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