Crown ether derivatives

Details Crown ether derivatives Crown ether derivatives

2005-11-08

2005-11-08

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C540S452000, C540S454000, C540S455000, C540S469000

Reexamination Certificate

active

06962992

ABSTRACT:
The invention describes crown ether chelators, including crown ethers having the formulaand aza-substituted and thia-substituted analogs thereof. These crown ethers are substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof.Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na+and K+ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.

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