Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from musculoskeletal system – other than cardiac muscle
Patent
1990-01-03
1992-11-17
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Derived from musculoskeletal system, other than cardiac muscle
514 2, 514 21, 530856, A61K 3558
Patent
active
051641968
ABSTRACT:
The present invention provides a stable composition of matter based on the cytotoxic activity of a basic phospholipase A.sub.2 of molecular weight 14,500 and isoelectric point 9.6-9.7 (crotoxin B) isolated from the venom of Crotalus durissus terrificus which in complex with a specific, non-enzymatic, peptide of molecular weight 9,500 and isoelectric point 3.5-3.7 (crotoxin A) displays a preferential cytotoxic activity against various types of tumor cells. When administered parenterally in an acceptable vehicle and in pharmacologically efficient amounts to animals and humans the complex is useful in the treatment of malignant tumors in advanced stages. The method for purification of the active components, the preparation in a pharmacologically acceptable form, and the method of therapeutic use of the present composition of matter are also disclosed.
REFERENCES:
patent: 4341762 (1982-07-01), Haast
patent: 4610879 (1986-09-01), Markland, Jr. et al.
patent: 4774318 (1988-09-01), Marquardt et al.
Gil, Antitumor Drug; CA105:165008 (1986).
Hendon et al., BA68(9):57778 (1979).
Wu et al., Journal of Chromatography 259:375-377 (1983).
Braganca, et al., Biochim. Biophys. Acta, 136:508-520 (1967).
Takechi, et al., Naturwissenschaften 58. Jg., Heft 6:323-324 (1971).
Cotte, et al., Toxicon 10:157-161 (1972).
Rubsamen, et al., Naunyn-Schmiedeberg's Arch. Pharmac. 270:274-288 (1971).
Hendon, et al., PNAS 68:1560-1563 (1971).
Aird, et al., Arch. Biochem. Biophys. 249:296-300 (1986).
Habermann, et al., Toxicon 16:19-30 (1978).
Breithaupt, et al., Eur. J. Biochem. 49:333-345 (1974).
Aird, et al., Biochemistry, 24:7054-7058 (1985).
Jeng, et al., PNAS, 75:600-604 (1978).
Bon, et al., Eur. J. Biochem., 99:471-481 (1979).
Volwerk, et al., Biochemistry, 13:1446-1454 (1974).
Wallach, Chapter 6, Biological Membranes, Chapman, ed., Academic Press, New York, 1973.
Coni Carlos M.
Costa Luis A.
Plata Guillermo J. H.
Vidal Juan C.
Robinson Douglas W.
Ventech Research Inc.
Witz Jean C.
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