Crosstalk inhibitors and their uses

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

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435 79, 435962, 436538, 436816, 436817, 436822, G01N 33543, G01N 3391, G01N 3374

Patent

active

055255248

ABSTRACT:
Assay for detecting the amount or presence of target ligand in a sample. The assay includes a ligand analogue conjugate having a linkage site and a binding site, a ligand receptor, and a sample. The assay includes the steps of providing at least one crosstalk inhibitor. This inhibitor, under assay conditions, competes with the linkage site of the ligand analogue conjugate for binding to the ligand receptor, and does not compete with the binding site of the ligand analogue conjugate for binding to the ligand receptor. In the invention, the assay is performed for the target ligand in the presence of a sufficient amount of the crosstalk inhibitor to reduce the amount of binding of the linkage site of the ligand analogue conjugate to the ligand receptor. The invention also features a method for identifying crosstalk inhibitors, and the crosstalk inhibitors themselves.

REFERENCES:
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patent: 5068277 (1991-11-01), Weinshenker
Hosoda et al 1983 "The Specificity of Enzyme Immunoassays for Plasma 11-Deoxycortisol" Chem. Pharm. Bull 31(10) 3595-3600.
Van Weemen, B. K. 1978 "Enzyme Immunoassay of Hormones" Scand. J. Immunol. vol. 8, Suppl 7, 73-82.
Huse W. D. et al., "Generation of A Large Combinatorial Library of the Immunoglobulin Repertoire In Phange Lambda" Science 246:1275-81 (1989).
ICN FLOW Catalog 1991-1992, pp. 42-44, 165, 604.
Kinoshita et al., "Enyme Immunoassay for Captopril," J. Pharmaceutical Sciences 75:711-713 (1986).
Pastor et al., "3-(4-Hydroxyphenylthio)pyrrolidine-2,5-diones," J. Heterocyclic Chem. 22:1195-1197.

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