Crosslinking of hyaluronan solutions and nanofiberous...

Details Crosslinking of hyaluronan solutions and nanofiberous... Crosslinking of hyaluronan solutions and nanofiberous...

2008-01-29

2008-01-29

Salvatore, Lynda (Department: 1771)

Fabric (woven, knitted, or nonwoven textile or cloth, etc.)

Nonwoven fabric

C424S424000, C424S425000, C442S333000

Reexamination Certificate

active

07323425

ABSTRACT:
A method for producing a non-chemically crosslinked hyaluronan is provided which involves contacting a sample of hyaluronan with an acidic solvent/water mixture for a period of time and at a temperature sufficient to effect crosslinking, wherein the acidic solvent/water mixture has a content of a solvent sufficient to prevent dissolution of said hyaluronan and wherein the solvent is miscible with water, and an amount of an acid sufficient to effect crosslinking of the hyaluronan, and the crosslinked, water resistant non-woven hyaluronan resulting therefrom.

REFERENCES:
patent: 5520916 (1996-05-01), Dorigatti et al.
patent: 7049434 (2006-05-01), Mariotti et al.
patent: 2004/0102124 (2004-05-01), Suzuki

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