Crosslinked, porous polymers for controlled drug delivery

Details Crosslinked, porous polymers for controlled drug delivery Crosslinked, porous polymers for controlled drug delivery

1983-08-15

1985-10-22

Moyer, Donald B.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

526262, 526264, 526320, 526332, 526333, 526334, 424 19, 424 80, 424 81, C08L 7500, C08G 7312, A61K 922

Patent

active

045489904

ABSTRACT:
A controlled-release, drug-delivery composition which comprises (A) a crosslinked copolymer, capable of swelling in ethanol to give a swollen copolymer containing at least 40% by weight of ethanol, and capable of swelling in water to give a swollen copolymer containing no more than 20% by weight of water, where the swelling ratio (% ethanol: % water) is 2:1 to 22:1, which comprises the copolymerization product of (a) 50 to 99% by weight of said copolymer of a water-insoluble monoolefinic monomer or (a) with 0 to 45% by weight of total monomers of a water-soluble monoolefinic monomer, with (b) 50 to 1% by weight, but not more than 20 mol % of a divinyl or polyvinyl crosslinking agent; and (B) an effective amount of a pharmaceutical medicament is useful for the controlled and prolonged release of drugs when taken orally.

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patent: 4224427 (1980-09-01), Mueller et al.
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