Crosslinked polyaspartate salts a process for their production

Details Crosslinked polyaspartate salts a process for their production Crosslinked polyaspartate salts a process for their production

1997-03-27

1999-11-09

Mosley, Terressa

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435 6, 435 72, 436521, 436536, 5303913, 536 231, 5363915, 548542, C07D23360

Patent

active

059817615

ABSTRACT:
A first embodiment comprises reacting PSI with polyhydrazide selected from the group consisting of dihydrazides and trihydrazides and mixtures thereof, subsequently hydrolyzing the crosslinked PSI with base to produce crosslinked polyaspartate. A second embodiment comprises reacting PSI with hydrazine to form an intermediate product which is reacted with polyacyl chloride or polyester to produce crosslinked PSI followed by hydrolysis to form crosslinked salt. Isolation of the intermediate before reaction with the polyacyl chloride or polyester is unnecessary.

REFERENCES:
patent: 4434228 (1984-02-01), Swann
patent: 4556689 (1985-12-01), Murakami et al.
patent: 4803168 (1989-02-01), Jarvis, Jr.
patent: 5062980 (1991-11-01), Migdal et al.
patent: 5142062 (1992-08-01), Knebel et al.
patent: 5247068 (1993-09-01), Donachy et al.
patent: 5284936 (1994-02-01), Donachy et al.
patent: 5461085 (1995-10-01), Nagatomo et al.
patent: 5478919 (1995-12-01), Koskan et al.
patent: 5484945 (1996-01-01), Nagatomo et al.
patent: 5525682 (1996-06-01), Nagatomo et al.
patent: 5525703 (1996-06-01), Kalota
patent: 5650270 (1997-07-01), Giese et al.
patent: 5834568 (1998-11-01), Chou
Abstract: JP07313178 relates to Pepn. of L-aspartic acid comprises acting (A) an enzyme-contg. material having both the activities of the maleic acid isomerase and aspartase or (B) an enzyme-contg. material having the activity of the isomerase and an enzyme-contg. material having the activity of the aspartase on a substrate medium congt. maleic acid, ammonia and an alkali metal ion to form L-aspartic acid and adding mineral acid to the reaction mixt. to filtrate and recover the crystals of L-aspartic acid and discharge waste liq. contg. Alkali metal salts(s) of the mineral acid.
Abstract: JP61015899A--relates to Novel protein-polysuccinimide complexes comprise a combination of (I) a physiological active protein and (II) a polysuccinimide deriv. of units (1)-(6): COCH(CH2.COX); COCH2CH(COX)NH; COCH(CH2COY); COCH2CH(COY)NH; COCH(CH2CONHWSZ)NH; COCH2CH(CONHWSZ); X is a reactive residue of a di-functional ligand cpd. having an amino gp. in the molecule.
Abstract: SU759545B--relates to Crosslinked poly-N-hydroxysuccinimides are of formula (I), where R is gp. of formulae (Ia), (Ib), or (Ic), and R' is CH2-CH2 or CH2-CH-C6H5.
G. Giammona, et al., "Crosslinked .alpha., .beta.-Polyasparthydrazide Micromatrices for Controlled Release of Anticancer Drugs", Journal of Bioactive and Compatible Polymers, vol. 10, Jan. 1995, pp. 28-40.
G. Giammona, et al., "Synthesis and Characterization of Water-Swellable .alpha., .beta.-Polyasparthydrazide Derivatives", Colloid & Polymer Science, pp. 1637-1641 (1994).
Giammona, G., et al., "Crosslinked .alpha., .beta.-Polyasparthydrazide Hydorgels: Effects of Crosslinking Degree and Loading Method on Cytarabine Release Rate", Journal of Controlled Release, vol. 41, No. 3, Sep. 1, 1996, pp. 195-203, XP000599778.
A.P. Wheeler, et al., "Large Scale Thermally Synthesized Polyaspartate as a Biodegradable Substitute in Polymer Applications", Mat. Res. Soc. Symp. Proc. vol. 292, 1993 Materials Research Society, pp. 277-283.
G. Giammona, et al., "A New Water-Soluble Synthetic Polymer, .alpha., .beta.-Polyasparthydrazide, as Potential Plasma Expander and Drug Carrier", Journal of Controlled Release, 29 (1994), pp. 63-72.

Affiliated with

Also associated with

Rating

Crosslinked polyaspartate salts a process for their production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crosslinked polyaspartate salts a process for their production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crosslinked polyaspartate salts a process for their production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1457958